DETECTION OF MUTATIONS, IN PARTICULAR DELETIONS OR INSERTIONS
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United States of America Patent
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Issued Date -
Nov 14, 2013
app pub date -
Jul 4, 2011
filing date -
Jul 9, 2010
priority date (Note) -
Abandoned
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Abstract
A method for detecting at least one gene modification, such as a mutation in a gene, such as a gene that codes for a protein associated with at least one of a tumor and a cancer. The method includes providing a detectable hybridization probe (sensor probe) which interacts with/binds to a gene not having a gene modification (wild type gene) and with a gene having a gene modification (mutation gene). The detectable hybridization probe (sensor probe) has at least one of a higher specificity, a higher binding affinity and a higher selectivity for the gene not having a gene modification (wild type gene) compared to the gene having a gene modification (mutation gene). At least one gene modification is detected with the detectable hybridization probe (sensor probe).
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