Methods for the Phenotypic Detection of HCV Inhibitor Resistant Subpopulations
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United States of America Patent
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Nov 14, 2013
app pub date -
Dec 3, 2012
filing date -
Dec 2, 2011
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Abstract
Methods and compositions for the efficient and accurate determination of susceptibility of a hepatitis C virus (HCV) population to an HCV inhibitor are provided. In certain aspects, the methods involve introducing into a cell a patient derived segment, wherein the cell or the patient derived segment comprises an indicator nucleic acid that produces a detectable signal that is dependent on the HCV; measuring the expression of the indicator gene in the presence of varying concentrations of the HCV inhibitor; determining a standard curve of susceptibility; comparing the IC95 fold change, slope, or maximum inhibition percentage of the HCV population to that of a control HCV population, and determining that the HCV population comprises HCV with a reduced susceptibility to the inhibitor when the IC95 fold change value is increased or the slope and/or maximum inhibition percentage is lower for the HCV population as compared to the control population.
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