DIAGNOSTIC TESTS FOR IMMUNE REACTIVITY WITH HUMAN ENDOTHELIAL CELL GROWTH FACTOR
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United States of America Patent
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Issued Date -
Nov 14, 2013
app pub date -
Sep 21, 2011
filing date -
Sep 21, 2010
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Abandoned
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Abstract
The present invention provides for methods and compositions for identifying and detecting autoantigens. Candidate autoantigens are identified by obtaining a subject sample from which HLA-DR-presented peptides are collected and identified using mass spectometry, then synthesized and reacted with the same subject peripheral blood or effected tissue. In particular, the present invention provides for endothelial cell growth factor as a novel autoantigen biomarker for Lyme disease-associated arthritis.
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