COMPOSITIONS AND METHODS FOR ALK MOLECULAR TESTING
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United States of America Patent
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Issued Date -
Oct 31, 2013
app pub date -
Apr 3, 2013
filing date -
Apr 27, 2012
priority date (Note) -
Abandoned
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Abstract
Disclosed herein are methods of predicting response of a tumor to an ALK inhibitor and methods of determining diagnosis or prognosis of a subject with a tumor. The methods can include detecting presence of an ALK gene fusion (such as EML4-ALK, TFG-ALK, or KIF5B-ALK) in a sample from a subject. Also disclosed herein are arrays for detecting the presence of ALK and/or ROS1 gene fusions in a sample. In some embodiments, the array includes one or more oligonucleotides complementary to an ALK or ROS1 gene fusion.
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