ENGINEERED KINETOCHORES AND USES THEREOF
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United States of America Patent
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Issued Date -
Oct 31, 2013
app pub date -
Oct 28, 2011
filing date -
Oct 28, 2010
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Abandoned
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Abstract
The invention provides modified DNA-binding kinetochore polypeptides, wherein the modified DNA binding kinetochore polypeptides comprise a heterologous DNA binding domain. The invention further provides engineered kinetochores containing the modified kinetochore polypeptides. Further provided are artificial chromosomes containing an engineered kinetochore. Cells containing an artificial chromosome containing an engineered kinetochore are also provided. Methods for producing and methods of using the engineered kinetochore, artificial chromosome, and cells are also provided.
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