METHODS AND COMPOSITIONS FOR DETERMINING VIRUS SUSCEPTIBILITY TO NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS
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United States of America Patent
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Issued Date -
Oct 17, 2013
app pub date -
Mar 4, 2013
filing date -
Mar 2, 2012
priority date (Note) -
Abandoned
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Abstract
Methods and compositions for the efficient and accurate determination of HIV susceptibility to a non-nucleoside reverse transcriptase inhibitor (NNRTI) are provided. In certain aspects, the methods involve detecting in a biological sample a nucleic acid encoding an HIV reverse transcriptase that comprises a mutation at codon 188, wherein the presence of the reverse transcriptase-encoding nucleic acid in the biological sample indicates that the HIV has a decreased susceptibility to an NNRTI. In certain embodiments, the HIV also contains one or more secondary mutations in reverse transcriptase. Also provided are methods for selecting a treatment for an HIV patient and methods for determining the selective advantage of a mutation or mutation profile.
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