HB-EGF DEFICIENT TRANSGENIC ANIMAL AND PRODUCTION METHOD THEREOF
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United States of America Patent
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Issued Date -
Oct 10, 2013
app pub date -
Jan 31, 2013
filing date -
Mar 9, 2012
priority date (Note) -
Abandoned
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Abstract
A transgenic animal other than human in which neuropsychiatric disorder condition is developed by the deletion of an HB-EGF gene is obtained. The present invention relates to a transgenic animal other than human in which an HB-EGF gene is deficient and neuropsychiatric disorder condition is developed, and a production method thereof, and a method for screening a therapeutic agent for neuropsychiatric disorder. As a transgenic animal in accordance with the present invention, a transgenic animal in which an HB-EGF gene is specifically deficient in the spiny neurons (striatum, and hippocampus) can be obtained by crossbreeding a transgenic animal that contains a genotype of Gng7(+/cre), and a transgenic animal that contains a genotype of Hb-egf(flox/flox).
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