BI-FUNCTIONAL shRNA TARGETING MESOTHELIN AND USES THEREOF
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United States of America Patent
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Issued Date -
Oct 3, 2013
app pub date -
Mar 28, 2013
filing date -
Mar 28, 2012
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Abandoned
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Abstract
The present invention includes bifunctional shRNAs capable of reducing an expression of a Mesothelin gene; wherein at least one target site sequence of the bifunctional RNA molecule is located within the Mesothelin, wherein the bifunctional RNA molecule is capable of activating a cleavage-dependent and a cleavage-independent RNA-induced silencing complex for reducing the expression level of Mesothelin.
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