CULTURED CARTILAGE TISSUE MATERIAL
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United States of America Patent
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Issued Date -
Oct 3, 2013
app pub date -
Mar 18, 2013
filing date -
Mar 30, 2012
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Abandoned
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Abstract
Provided is a cultured cartilage tissue material which enables formation of cartilage tissue being substantially the same as the cartilage tissue actually in the living body, and which is large in volume. The cultured cartilage tissue material is to be used for cartilage regeneration and comprises chondrocytes, and is a mixed body of chondrocytes in a concentration of 1×107 to 1×109 cells/cm3, and a bioabsorbable polymer. A thickness of the thinnest part of the cultured cartilage tissue material is 2.2 to 100 mm. A volume ratio between the chondrocytes and the bioabsorbable polymer is 7:3 to 9.5:0.5. A production amount of glycosaminoglycan is 0.001 to 0.2 ng per unit cell. A content ratio between type I collagen and type II collagen is 10:90 to 1:99. A content of type II collagen is 0.01 to 0.65 mg per 1 mg of dry weight of tissue.
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