Modified Mareks Disease Virus, and Vaccines Made Therefrom
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United States of America Patent
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Issued Date -
Sep 26, 2013
app pub date -
Mar 15, 2013
filing date -
Mar 22, 2012
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Abstract
The present invention provides an effective vaccine for Marek's disease, which may be prepared using a recombinant Marek's Disease Virus (MDV), strain CVI988, having been transformed with a foreign DNA construct that includes a long terminal repeat sequence of a reticuloendotheliosis virus. This safe viral agent elicits a highly protective immune response in a chicken against virulent MDV challenge without causing a significant degree of pathogenicity. Suitable formulations of the vaccine for use in chickens include an effective immunization dosage of this novel viral agent, along with a pharmaceutically acceptable carrier or diluent.
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