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Abstract

The present invention relates to synergistic immunogenic compositions for preventing whooping cough and infections caused by Streptococcus pneumoniae. Additionally, the compositions according to the present invention may protect against infections caused by other pathogenic agents by means of a synergistic combination of antigens thereof. In particular, the present invention provides synergistic immunogenic compositions that comprise at least one cell antigen of inactivated Bordetella pertussis and at least one protein antigen comprising one or more surface proteins A (PspA) of Streptococcus penumoniae or fragments thereof. The present invention further provides synergistic immunogenic compositions comprising at least one cell antigen of inactivated Bordetella pertussis, at least one protein antigen comprising one or more surface proteins A (PspA) of Streptococcus penumoniae or fragments thereof, and one or more diphtheria and/or tetanus toxins. The present invention also relates to the use of one or more synergistic immunogenic compositions according to the present invention for producing combined vaccines for the prevention of whooping cough, tetanus, diphtheria and/or infections caused by Streptococcus pneumoniae. The present invention further relates to the use of the compositions according to the present invention for producing vaccines for the prevention of whooping cough, tetanus, diphtheria and/or infections caused by Streptococcus pneumoniae.

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First Claim