IDURONATE-2-SULFATASE AND USE THEREOF
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United States of America Patent
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Issued Date -
Sep 12, 2013
app pub date -
Nov 12, 2010
filing date -
Nov 12, 2010
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Abstract
Disclosed is a modified iduronate-2-sulfatase (IDS) gene constructed by inserting the nucleotide of SEQ ID NO: 2 into a wild-type IDS gene. In addition to being negatively charged, the improved IDS enzyme encoded by the modified gene exhibits a sufficient retention time in blood to target the bone, so that it is more effective for treating Hunter syndrome.
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