SUBSTANCES AND COMPOSITIONS FOR ENHANCING DNA REPAIR AND METHODS OF USE
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United States of America Patent
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Aug 20, 2013
Grant Date -
Feb 24, 2011
app pub date -
Apr 29, 2009
filing date -
Apr 29, 2008
priority date (Note) -
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status (Latency Note)
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Abstract
The invention provides methods of preventing or treating a condition associated with DNA damage in an animal comprising the administration of a substance that interferes with the activity of the CUL4A ubiquitin ligase. The invention also provides a substance that interferes with the activity of CUL4A, as well as compositions comprising the interfering substance and a carrier. The substance of the invention preferably enhances nucleotide excision repair activity in an animal. The invention further provides methods of identifying substances that negatively or positively modulate the expression and/or activity of CUL4A.
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International Classification(s)
- A61K:PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOS....
- C07H:SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTI....
- C12Q:MEASURING OR TESTING PROCESSES INVOLVING ENZYMES O....
- G01N:INVESTIGATING OR ANALYSING MATERIALS BY DETERMININ....
- C08B:POLYSACCHARIDES; DERIVATIVES THEREOF
- A61P:THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDI....
- A61Q:USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
- C07K:PEPTIDES
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