Proteasome inhibitors and uses thereof
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United States of America Patent
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Mar 22, 2016
Grant Date -
Aug 29, 2013
app pub date -
Apr 29, 2013
filing date -
May 27, 2009
priority date (Note) -
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Abstract
A method of treating a disease in which inhibiting of a proteasome is advantageous is provided. The method comprises administering to the subject a therapeutically effective amount of a compound which binds to a proteasome of a cell, the compound comprising a copper bound to a ligand, the ligand being configured such that upon binding to the proteasome, the copper interacts with cysteine 31 of a Beta2 subunit of the proteasome and further interacts with cysteine 118 of a Beta3 subunit of the proteasome, thereby treating the disease. Additional novel proteasome inhibitors are also provided as well as methods of identifying proteasome inhibitors.
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