Four-gene pathway for wax ester synthesis

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United States of America Patent

PATENT NO 8962299
SERIAL NO

13408270

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Abstract

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The invention relates to methods for producing a wax ester in recombinant host cells engineered to express a thioesterase, an acyl-CoA synthetase, an alcohol-forming fatty acyl reductase, and a wax ester synthase. The methods of the invention may take place in photosynthetic microorganisms, and particularly in cyanobacteria. Isolated nucleotide molecules and vectors expressing the thioesterase, acyl-CoA synthetase, alcohol-forming fatty acyl reductase, and wax ester synthase, recombinant host cells expressing the thioesterase, acyl-CoA synthetase, alcohol-forming fatty acyl reductase, and wax ester synthase, and systems for producing a wax ester via a pathway using these four enzymes, are also provided.

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Patent Owner(s)

Patent OwnerAddress
EXXONMOBIL RESEARCH AND ENGINEERING COMPANY1545 ROUTE 22 EAST P O BOX 900 ANNANDALE NJ 08801-0900

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Holtzapple, Erik San Diego, US 10 51
Verruto, John H San Diego, US 8 37

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