METHODS AND ASSAYS FOR TREATING OR PREVENTING OBESITY AND/OR DIABETES OR INCREASING INSULIN SENSITIVITY

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United States of America Patent

APP PUB NO 20130224222A1
SERIAL NO

13641624

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention provides methods for determining a putative agent that treats or prevents obesity and/or diabetes or increasing insulin sensitivity, the method comprising contacting cells with the putative agent and measuring thioredoxin-interacting protein (TXNIP) or thioredoxin expression or activity in the cells. The present invention also provides the agent, the pharmaceutical composition, and methods of preventing or treating obesity and/or diabetes or of increasing insulin sensitivity or glucose sensitivity, the method comprising administration of the agent that decreases the expression of TXNIP or activity of TXNIP.

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Patent Owner(s)

Patent OwnerAddress
ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY1300 MORRIS PARK AVENUE BRONX NY 10461

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Blouet, Clemence New York, US 1 0
Schwartz, Gary J Bronx, US 9 99

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