FUSION PROTEIN CONTAINING VEGI, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF
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United States of America Patent
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Issued Date -
Aug 15, 2013
app pub date -
Dec 27, 2010
filing date -
Oct 27, 2010
priority date (Note) -
Abandoned
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Abstract
Provided is an anti-angiogenic fusion protein, which comprises a vascular endothelial cell growth inhibitor (VEGI) or variant thereof, and other polypeptide such as IgG Fc. The fusion protein optionally comprises a linker. The fusion protein can induce the apoptosis of endothelial cells and inhibit the growtth of endothelial cells, so as to be used for treating tumor. Also provided are a pharmaceutical composition and use of the fusion protein.
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