SCREENING METHODS FOR COMPOUNDS THAT MODULATE THE ACTIVITY OF G-PROTEIN COUPLED RECEPTORS
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Mar 14, 2013
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Jun 7, 2006
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Abstract
The present invention relates to a screening system for modulators of GPCRs. Further it relates to recombinant vector systems for the heterologous expression of heterodimeric G-protein coupled receptors (GPCRs) in eukaryotic host cells. Preferably the functional expression of engineered GPCRs for the perception of sweet and L-amino acid taste or more preferably the use of these receptors for the identification of functional ligands is also encompassed.
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