I-CREI HOMING ENDONUCLEASE VARIANTS HAVING NOVEL CLEAVAGE SPECIFICITY AND USE THEREOF

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United States of America Patent

SERIAL NO

13744068

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A method for engineering I-CreI homing endonuclease variants able to cleave mutant I-CreI sites having variation in positions ±8 to ±10. A I-CreI homing endonuclease variant obtainable by said method, a vector encoding said variant, a cell, an animal or a plant modified by said vector. Use of said I-CreI endonuclease variant and derived products for genetic engineering, genome therapy and antiviral therapy.

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Patent OwnerAddress
CELLECTIS75013 PARIS

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Paques, Frederic Bourg La Reine, FR 19 292

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