METHODS OF KINOME ANALYSIS
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United States of America Patent
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Issued Date -
Aug 8, 2013
app pub date -
Jun 30, 2011
filing date -
Jun 30, 2010
priority date (Note) -
Abandoned
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Abstract
Method for analyzing phosphorylation data of a plurality of peptides are provided, the method comprising obtaining one or more datasets, each dataset comprising a phosphorylation signal intensity for each replicate of the plurality of peptides for a sample; transforming the phosphorylation signal intensity of each replicate of the plurality of peptides using a variance stabilizing transformation to provide a variance stabilized signal intensity for each replicate of the plurality of peptides; and identifying one or more peptides of the plurality of peptides that is/are consistently phosphorylated or consistently unphosphorylated.
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