ANTIGEN-BINDING MOLECULE AND USES THEREOF
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United States of America Patent
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Issued Date -
Jul 25, 2013
app pub date -
Dec 26, 2012
filing date -
Feb 25, 2010
priority date (Note) -
Abandoned
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Abstract
In one aspect, the present invention relates to an antigen-binding molecule specific for albumin and CD3 which may comprise two polypeptide chains, each polypeptide chain having at least four variable domains in an orientation preventing Fv formation and the two polypeptide chains are dimerized with one another thereby forming a multivalent antigen-binding molecule. On each of the two polypeptide chains the four variable domains may be arranged in the order VLA-VHB-VLB-VHA from the N-terminal to the C-terminal of the polypeptide. Compositions of the antigen-binding molecule and the methods of using the antigen-binding molecule or the compositions thereof for treatment of various diseases are also provided herein.
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