SILENCING OF CSN5 GENE EXPRESSION USING INTERFERING RNA
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United States of America Patent
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Issued Date -
Jul 11, 2013
app pub date -
Jul 17, 2012
filing date -
Apr 15, 2008
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Abandoned
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Abstract
The present invention provides compositions comprising nucleic acids that target CSN5 gene expression and methods of using such compositions to silence CSN5 gene expression. More particularly, the present invention provides unmodified and chemically modified interfering RNA molecules which silence CSN5 gene expression and methods of use thereof, e.g., for treating cell proliferative disorders such as cancer. The present invention also provides nucleic acid-lipid particles that target CSN5 gene expression comprising an interfering RNA molecule, a cationic lipid, a non-cationic lipid, and optionally a conjugated lipid that inhibits aggregation of particles.
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