COMBINATION OF CATIONIC POLYMERS AND POLYSACCHARIDES NANOPARTICLES AS A GENE CARRIER
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Mar 1, 2013
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Jul 25, 2011
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Abstract
The present invention discloses a gene carrier and the preparation method thereof. The chondroitin sulfate (CS) is reacted with methacrylic anhydride (MA) to form a chondroitin sulfate-methacrylate (CSMA), which is further covalently bound with 2-(dimethylamino)ethyl methacrylate (DMAEMA) to form the “CM-DM” gene carrier. The novel nonviral and lower cytotoxic gene delivery vector/carrier with the sugar functionality reduced the cytotoxicity of poly(2-dimethylaminoethyl methacrylate) (PDMAEMA), and can successfully deliver plasmid DNA to cancer cells via the caveolae-mediated and CD44-mediated endocytosis mechanisms.
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