DETECTION OF ANTIGEN-SPECIFIC PERIPHERAL BLOOD MONONUCLEAR CELLS AND METHODS FOR DIAGNOSING IMMUNE DISORDERS

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United States of America Patent

APP PUB NO 20130177925A1
SERIAL NO

13704823

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Abstract

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The present invention relates to a method for detecting the presence or the absence, and optionally quantifying and/or isolating, antigen-specific peripheral blood mononuclear cells. This method, which involves flow cytometry, is based on the use of a fluorescently-labeled antibody specifically recognizing peripheral blood mononuclear cells, and of fluorescently-labeled beads coated with at least one antigen that is specifically recognized by antigen-specific peripheral blood mononuclear cells. The method according to the invention is for example useful for diagnosing immune disorders such as transplant rejections and autoimmune disorders.

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Patent Owner(s)

Patent OwnerAddress
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)101 RUE DE TOLBIAC PARIS 75013
UNIVERSITE DE NANTESNANTES FRANCE NANTES LOIRE-ATLANTIQUE
CHU NANTES44000 NANTES

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Akl, Ahmed Nantes, FR 3 0
Brouard, Sophie Nantes, FR 17 11
Soulillou, Jean Paul Nantes, FR 1 0

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