DALBAVANCIN COMPOSITIONS FOR TREATMENT OF BACTERIAL INFECTIONS
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United States of America Patent
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app pub date -
Aug 3, 2012
filing date -
Nov 18, 2002
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Abstract
The invention provides methods for drying dalbavancin. The method includes providing wet dalbavancin that includes dalbavancin, water, and a solvent. The wet dalbavancin is dried at at a temperature of about 30° C. or less, at a vacuum pressure of about 50 mbar or less, until the water level of the wet dalbavancin is less than about 20% (w/w). Water is then added to the dalbavancin and the resulting wet dalbavancin is dried at least once more at a temperature of about 30° C. or less, at a vacuum pressure of about 50 mbar or less, until the solvent level of the dalbavancin is less than about 3.0% (w/w).
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