Sugar-chain modified yeast and method for producing glycoprotein using the same
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United States of America Patent
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Apr 28, 2015
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Jul 4, 2013
app pub date -
Mar 1, 2012
filing date -
Jan 4, 2011
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Abstract
The present invention provides: genetically modified yeasts such as mutant yeasts having an ability to produce N-linked sugar chains of Man5GlcNAc2 and a decreased ability to produce O-linked sugar chains, mutant yeasts having an ability to produce N-linked sugar chains of Man5GlcNAc2 and further having an ability to produce N-linked sugar chains of GlcNAc1Man5GlcNAc2, and mutant yeasts having an increased ability to produce and secrete proteins and an ability to produce N-linked sugar chains of Man5GlcNAc2; and a method for producing glycoproteins using them.
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