VIRAL VARIANTS AND METHODS FOR DETECTING SAME
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United States of America Patent
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Jul 12, 2012
filing date -
Nov 8, 1996
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Abstract
The present invention relates generally to viral variants exhibiting reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B variants exhibiting complete or partial resistance to nucleoside analogs and/or reduced interactivity with antibodies to viral surface components. The present invention further contemplates assays for detecting such viral variants which assays are useful in monitoring anti-viral therapeutic agents.
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