REDUCTION IN BACTERIAL COLONIZATION BY ADMINISTERING BACTERIOPHAGE COMPOSITIONS

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United States of America Patent

SERIAL NO

13772573

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Abstract

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The present invention provides a method for reducing the risk of bacterial infection or sepsis in a susceptible patient by treating the susceptible patient with a pharmaceutical composition containing bacteriophage of one or more strains which produce lytic infections in pathogenic bacteria. Preferably, treatment of the patient reduces the level of colonization with pathogenic bacteria susceptible to the bacteriophage by at least one log. In a typical embodiment, the susceptible patient is an immunocompromised patient selected from the group consisting of leukemia patients, lymphoma patients, carcinoma patients, sarcoma patients, allogeneic transplant patients, congenital or acquired immunodeficiency patients, cystic fibrosis patients, and AIDS patients. In a preferred mode, the patients treated by this method are colonized with the pathogenic bacteria subject to infection by said bacteriophage.

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Patent Owner(s)

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INTRALYTIX INCCOLUMBIA MD 21046

International Classification(s)

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  • 2013 Application Filing Year
  • A61K Class
  • 12711 Applications Filed
  • 11051 Patents Issued To-Date
  • 86.95 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances2013201420152016201720182019202020212022202320240255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Alavidze, Zemphira Tbilisi, GE 12 331
Brown, Torrey C Severna Park, US 10 183
MORRIS, J Glenn Baltimore, US 5 31
Pasternack, Gary R Baltimore, US 38 438
Sulakvelidze, Alexander Towson, US 30 304

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  • A61K Class
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  • 12 Age
Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges93340159383591527830328862201 - 1011 - 2021 - 3031 - 4041 - 5051 - 6061 - 7071 - 8081 - 9091 - 100100 +025050075010001250150017502000225025002750300032503500375040004250

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