PROCESS FOR CONJUGATION OF NHS ESTERS WITH OLIGONUCLEOTIDES
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United States of America Patent
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Issued Date -
Jun 20, 2013
app pub date -
Dec 19, 2012
filing date -
Dec 19, 2011
priority date (Note) -
Abandoned
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Abstract
The present invention provides processes for the conjugation of NHS esters to amino-modified oligonucleotides. The processes provide the amino-modified oligonucleotide on a solid support such that conjugation can be carried out under conditions that can accommodate a wide variety of NHS esters and oligonucleotides.
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