FULLY HUMAN ANTIBODIES SPECIFIC TO CADM1
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United States of America Patent
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Issued Date -
Jun 20, 2013
app pub date -
Dec 27, 2012
filing date -
Mar 5, 2009
priority date (Note) -
Abandoned
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Abstract
The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, more particularly engineered antibodies resulting in increased binding to Fc receptors and/or increased potency for ADCC or immunoconjugates, which specifically bind to CADM1 with high affinity. Nucleic acid molecules encoding CADM1 antibodies, expression vectors, host cells and methods for expressing the CADM1 antibodies are also provided. Bispecific molecules and pharmaceutical compositions comprising the CADM1 antibodies are also provided. Methods for detecting CADM1, as well as methods for treating various cancers, including lung cancer and pancreatic cancer, are disclosed.
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