T CELL RECEPTOR MUTANTS
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United States of America Patent
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app pub date -
Oct 9, 2012
filing date -
Jul 28, 2010
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Abandoned
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Abstract
A T cell receptor (TCR) having the property of binding to EVDPIGHLY HLA-A1 complex and comprising a specified wild type TCR which has specific mutations in the TCR alpha variable domain and/or the TCR beta variable domain to increase affinity. Such TCRs are useful for adoptive therapy.
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