EXPEDITIOUS SYNTHESIS OF UBIQUITINATED PEPTIDE CONJUGATES
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United States of America Patent
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Issued Date -
Jun 6, 2013
app pub date -
Jun 1, 2011
filing date -
Jun 1, 2010
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Abandoned
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Abstract
The present invention discloses a process for preparing ubiquinated peptide conjugates comprising a ubiquitin peptide residue UR attached at its C-terminus to a substrate peptide via a native isopeptide bond, this process comprising combining Native Chemical Ligation (NCL) and solid phase peptide synthesis (SPPS). Further are disclosed ubiquinated peptide conjugates containing a native isopeptide bond, as well as various uses thereof.
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