Anti-cocaine compositions and treatment
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United States of America Patent
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Dec 1, 2015
Grant Date -
May 30, 2013
app pub date -
Nov 14, 2012
filing date -
Jul 10, 2006
priority date (Note) -
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Abstract
Embodiments of the invention disclosed herein generally relate to anti-cocaine therapeutics. Specifically, some embodiments of the invention relate to highly efficient, thermostable, and long-lasting cocaine esterase (CocE) mutants that can protect against the toxic and reinforcing effects of cocaine in subjects. Provided herein are mutant CocE polypeptides displaying thermostable esterase activity. Also provided are methods of treating cocaine-induced conditions in a subject in need via administration of mutant CocE as well as methods for high-throughput screening of candidate esterase polypeptides.
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