PHYLLANTHUS AMARUS COMPOSITIONS AND METHOD OF EXTRACTING SAME
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United States of America Patent
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Issued Date -
May 16, 2013
app pub date -
Nov 1, 2012
filing date -
Nov 1, 2011
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Abandoned
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Abstract
An enriched hydrolyzable tannin blend derived from Phyllanthus amarus is provided. An optimized aqueous extraction method for Phyllanthus amarus is provided to maximize the levels of bioactive hydrolyzable tannins including corilagin, geraniin, nirurin and other low molecular weight hydrolyzable tannoids. The method produces a Phyllanthus amarus extract containing a hydrolyzable tannin blend as an amorphous dry powder. In an embodiment, the Phyllanthus amarus extract contains 7-13% by weight corilagin, 3.5-10% nirurin, 1-2% geraniin, and 9-20% low molecular weight hydrolyzable tannoids. In another embodiment, the Phyllanthus amarus extract contains 12-20% geraniin and 12-20% low molecular weight hydrolyzable tannoids. Potential uses of said enriched hydrolyzable tannin compositions for hepatoprotection in a human subject are described herein.
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