V. Cholera hypereexpressing recombinant cholera toxin B subunit showing dual immunogenicity
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United States of America Patent
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Issued Date -
May 16, 2013
app pub date -
Oct 16, 2012
filing date -
Apr 24, 2007
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Abstract
Immunogenic compositions imparting dual protection against enterotoxigenic labile toxin (LT)-expressing Escherichia coli (ETEC) and Vibrio cholerae based on the hyperexpression of recombinant cholera toxin B antigen by attenuated, live bacterial vectors derived from Vibrio cholerae are disclosed. The compositions exhibit dual immunogenicity and retain the ability to colonize gastrointestinal mucosa-associated lymphoid tissues.
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