NEW BINDER-DRUG CONJUGATES (ADCS) AND USE THEREOF
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Issued Date -
May 16, 2013
app pub date -
Apr 20, 2012
filing date -
Apr 21, 2011
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Abstract
The present application relates to new binder-drug conjugates (ADCs) of N,N-dialkylauristatins that are directed against the target mesothelin, to active metabolites of these ADCs, to processes for preparing these ADCs, to the use of these ADCs for treating and/or preventing illnesses, and also to the use of these ADCs for producing medicaments for treating and/or preventing illnesses, more particularly hyperproliferative and/or angiogenic diseases such as, for example, cancer diseases. Such treatments may be practised as a monotherapy or else in combination with other medicaments or further therapeutic measures.
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