Methods and Compositions for Prognosing, Detecting, and Treating Age-Related Macular Degeneration
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United States of America Patent
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Issued Date -
May 16, 2013
app pub date -
Jul 9, 2012
filing date -
Feb 16, 2007
priority date (Note) -
Abandoned
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Abstract
The invention provides methods and compositions for determining whether a subject is at risk of developing age-related macular degeneration, for example, the wet or neovascular form of age-related macular degeneration. The method involves determining whether the subject has a protective variant and/or a risk variant at a polymorphic site in the HTRA1 gene. In addition, the invention provides a method of treating or slowing the progression of age-related macular degeneration by reducing the expression of the HTRA1 gene, or reducing the biological activity of the HTRA1 gene product.
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