Use of Interleukin-1 Beta Mutein Conjugates in the Treatment of Diabetes

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United States of America Patent

APP PUB NO 20130115189A1
SERIAL NO

13395099

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Abstract

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The present invention provides compositions, pharmaceutical compositions and vaccines for the treatment, amelioration and/or prophylaxis of type II diabetes. The compositions, pharmaceutical compositions and vaccines of the invention comprise a virus-like particle of an RNA bacteriophage and an antigen, wherein said antigen comprises an interleukin-1 beta (IL-1β) mutein. When administered to an animal, preferably to a human, said compositions, pharmaceutical compositions, and vaccines induce efficient immune responses, in particular antibody responses, wherein typically and preferably said antibody responses are directed against IL-1β. Thus, the invention provides methods of treating, ameliorating or preventing type II diabetes by way of active immunization against IL-1β.

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CYTOS BIOTECHNOLOGY AG8952 ZÜRICH-SCHLIEREN

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bachmann, Martin F Ramismuhle, CH 55 696
Maurer, Patrik Winterthur, CH 24 502
Spohn, Gunther Zurich, CH 9 48

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