ANTI-APOPTOTIC PROTEIN ANTIBODIES
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United States of America Patent
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Issued Date -
May 2, 2013
app pub date -
Dec 19, 2012
filing date -
Sep 1, 2005
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Abandoned
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Abstract
Single-domain antibodies that bind pro-apoptotic proteins Bax and caspase-3 are identified and isolated. These single-domain antibodies may be used to modulate the activity of Bax and caspase-3, thereby modulating the symptoms and steps of oxidative stress and/or cell apoptosis, including Bax dimerization, mitochondrial permeabilization and the release of apoptotic proteins.
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