Antibodies with Enhanced or Suppressed Effector Function
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United States of America Patent
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Issued Date -
May 2, 2013
app pub date -
Mar 28, 2011
filing date -
Mar 29, 2010
priority date (Note) -
Abandoned
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Abstract
Rationally designed antibodies and polypeptides that comprise two Fc region amino acid substitutions that synergistically provide enhanced selectivity and binding affinity to a target Fc receptor are provided. The polypeptides comprise Fc region mutations at two positions that synergistically make the polypeptides more effective when incorporated in antibody therapeutics than those having wild-type Fc components.
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