NEUBLASTIN VARIANTS
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United States of America Patent
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app pub date -
Jul 3, 2012
filing date -
Aug 19, 2004
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Abandoned
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Abstract
Variant Neublastin polypeptides having substitutions at selected amino acid residues are disclosed. Substitution at one or more selected amino acid residues decreases heparin binding and increases serum exposure of variant Neublastin polypeptides. Also disclosed are methods of using variant Neublastin polypeptides to treat disorders and activate the RET receptor in a mammal.
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