DYE COMPOSITIONS AND DYE SYNTHESES
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United States of America Patent
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Issued Date -
Apr 18, 2013
app pub date -
Jun 29, 2011
filing date -
Jun 29, 2010
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Abstract
The present invention relates to sulfonated unsymmetrical pentamethine optical dye compositions, especially dyes suitable for biological applications in vitro, and for in vivo imaging. Improved dye compositions and intermediates are provided, which enable the suppression of undesirable newly-identified impurities. Also provided is the use of the improved dye compositions in the preparation of conjugates with biological targeting molecules.
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