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Abstract

Disclosed is a transformant in which polynucleotides comprising a nucleotide sequence encoding the amino acid sequence of all of the following proteins (1) to (3) are transfected into a microbial cell:

(1) a protein that is capable of binding to FK506 and has a molecular weight of 15,000 or more and 60,000 or less;(2) a prolyl hydroxylase; and(3) a glycine repeat sequence protein having the following characteristics (A) and (B): the polypeptide chain of the glycine repeat sequence protein having a continuous, Gly-Xaa-Yaa repeating sequence, and an imino acid being contained in the continuous, Gly-Xaa-Yaa repeating sequence of the polypeptide chain of the glycine repeat sequence protein.

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First Claim