PROCESS FOR PURIFYING VITAMIN K DEPENDENT PROTEINS SUCH AS COAGULATION FACTOR IX
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United States of America Patent
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Mar 28, 2013
app pub date -
Mar 30, 2011
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Mar 30, 2010
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Abstract
A process of manufacturing a prion-free Vitamin K dependent Protein in a purification sequence employing chromatography characterized in that
- at least one chromatography step is performed using a multimodal resinproviding a fraction containing Vitamin K dependent Protein in an aqueous solution;contacting the fraction containing the Vitamin K dependent Protein with a multimodal resin at a pH between 6-9;optionally washing the multimodal resin having the Vitamin K dependent Protein adsorbed with an aqueous washing buffer to wash away contaminants and retain the Vitamin K dependent Protein, before the Vitamin K dependent Protein is eluted;the Vitamin K dependent Protein is eluting from the multimodal resin at a pH between 6 to 9 in a buffer comprising arginine; andoptionally collecting Vitamin K dependent Protein containing fractions in purified or enriched form.
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