PEPTIDOMIMETIC MACROCYCLES
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United States of America Patent
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N/A
Issued Date -
N/A
app pub date -
Sep 22, 2010
filing date -
Sep 22, 2009
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
Disclosed are peptidomimetic macrocycles comprising a helix, such as an alpha helix, and methods of using such macrocycles for the treatment of disease such as cancer. In other aspects, the peptidomimetic macrocycle comprises an a,a-disubstituted amino acid, or may comprise a crosslinker linking the a-positions of at least two amino acids or at least one of said two amino acids may be an a,a-disubstituted amino acid. Further included is the targeting of components of the Wnt signaling pathway such as the Tcf4-/3-catenin complex.
First Claim
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