Amphiphilic Cationic Polymers and Methods of Use Thereof
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United States of America Patent
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Issued Date -
Mar 21, 2013
app pub date -
Sep 14, 2012
filing date -
Sep 16, 2011
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Abstract
Amphiphilic cationic polymers comprising a biocompatible amphiphile linked to an organic cation are provided. The polymers complex with therapeutic agents and facilitate delivery of such therapeutic agents, particularly therapeutic nucleic acids, both in vitro and in vivo. Accordingly, the invention further provides methods of facilitating delivery of therapeutic and/or diagnostic agents to a cell and methods of treating a condition, such as a disease or infection, in an organism using the amphiphilic cationic polymers of the invention.
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