USE OF ENDOGENOUS PROMOTERS TO EXPRESS HETEROLOGOUS PROTEINS
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United States of America Patent
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Issued Date -
Mar 14, 2013
app pub date -
Apr 13, 2011
filing date -
Apr 13, 2010
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Abandoned
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Abstract
The present invention provides methods for using endogenous transcriptional control systems to regulate the expression of heterologous protein(s). In particular, targeted genome editing is used to integrate a sequence encoding the heterologous protein(s) in-frame with an endogenous coding sequence such that the expression of the heterologous and endogenous sequences is regulated by the endogenous control system.
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