Gastroretentive Solid Oral Dosage Forms with Swellable Hydrophilic Polymer
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United States of America Patent
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Dec 28, 2010
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Dec 29, 2009
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Abstract
The disclosure provides multiparticulate systems that give release of active agents with a narrow window of absorption such that there is bioavailability to a patient. The disclosure provides a composition comprising microparticulates comprising a swellable hydrophilic polymer and an active agent, wherein the swellable hydrophilic polymer is substantially non-crosslinked intramolecularly, and the size of the microparticulates is about 500 μm or less.
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