FC-FREE ANTIBODIES COMPRISING TWO FAB FRAGMENTS AND METHODS OF USE
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United States of America Patent
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Mar 7, 2013
app pub date -
Aug 21, 2012
filing date -
Aug 23, 2011
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Abstract
The present invention relates to bispecific antibodies comprising at least two fab fragments, wherein the first Fab fragment comprises at least one antigen binding site specific for a first antigen; and the second Fab fragment comprises at least one antigen binding site specific for a second antigen, wherein either the variable regions or the constant regions of the second Fab heavy and light chain are exchanged; and wherein the bispecific antibody is devoid of a Fc domain; methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
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