NEGATIVELY CHARGED POROUS MEDIUM FOR REMOVING PROTEIN AGGREGATES
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United States of America Patent
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Issued Date -
Mar 7, 2013
app pub date -
Feb 26, 2010
filing date -
Feb 27, 2009
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Abandoned
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Abstract
A negatively charged microporous filtration medium having a high charge density comprising a porous substrate and a polymerized cross-linked polymeric coating located on the inner and outer surfaces of the substrate. The coating may be formed from a reactant solution comprising negatively charged cross-linkable polymerizeable acrylamidoalkyl monomers and acrylamido cross-linking agents which are polymerized in situ on the substrate. The negatively charged microporous filtration medium are suitable for use as prefiltration membranes for selectively removing protein aggregates from a protein solution.
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